Bombay Hospital Journal ABSTRACTSContentsHomeArchivesSearchBooksFeedback

ABSTRACTS OF PAPERS AT THE 89TH RESEARCH MEETING OF THE MEDICAL RESEARCH CENTRE OF BOMBAY HOSPITAL ON MONDAY, 13TH AUGUST, 2001, 2.30 PM SP JAIN CAFETERIA (CONVENOR DR. HL DHAR)

1. THE MOLECULAR NEUROPATHOLOGY OF MUSCULAR DYSTROPHIES

Rashna S Dastur, Daya K Manghani
Muscular dystrophy covers a diverse group of inherited disorders in which the main clinical defects in the skeletal muscle i.e. weakness and wasting are mainly similar in all patients, but show genetically different diseases. This suggests that the various gene products participate or work together as a common functional structure or "biochemical cascade". In striated muscle cells, dystrophin - glycoprotein complex (DGC) serves as a link between the extracellular matrix and the subsarcolemmal cytoskeleton.

The absence or dysfunction of one gene product (protein) in the DGC affects the functioning of the others causing the muscle cell to breakdown. Variability of clinical severity and the age of onset found in different types of dystrophies therefore depend on the functional importance of their gene products to the complex.
Cohen’s technique for reimplantation was used in 40 patients (73 ureters), Leadbetter-Politano Technique in 31 patients (41 ureters), Lich-Gregoir Technique in 11 patients (15 ureters), and Paquin’s Technique in 9 patients (11 ureters). Ureteric tailoring was performed in 27 ureters while ureteric plication was done in 11 ureters. Ureteric stents were placed post-operatively in 94 ureters.

The focus on the recent findings about muscular dystrophies, especially duchenne muscular dystrophy caused by mutations in the DGC components will be illustrated through immunohistochemical staining and discussed.



2. SPONTANEOUS INTRACRANIAL HYPOTENSION

Rahul T Chakor, NE Bharucha

We present a case of 36 year old man with orthostatic headache. Clinically low CSF pressure headache was suspected. CT brain showed effacement of basal cisterns, brain stem swelling and bilateral thin subdural collection. The third and lateral ventricles were chinked. MRI (enhanced) showed diffuse pachymeningeal enhancement. Descent of brainstem effacement of basal cisterns. Bilateral chronic subdural collection. The imaging findings were consistent of intracranial hypotension. No further invasive tests were done to demonstrate CSF leak. One week later his sensorium worsened and subdural collection increased. Tapping of subdural collection was done after which he improved. He was asymptomatic with two weeks of complete bed rest in head low position and hydration. CT brain two months later did not show increase in size of subdural collection. We conclude that MRI (enhanced) findings are diagnostic of intracranial hypotension. Invasive tests may not be required tapping. Conservative treatment with complete bed rest for two weeks may be satisfactory method of treatment.


To section TOC
Sponsor-Dr.Reddy's Lab