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OP Kapoor
 

Osteoporosis is very common in post-menopausal women specially after 10 years of menopause but in elderly males it is often seen at the age of around 75-80 years.

I would like to point out that very often old patients have in addition osteomalacia, which is due to deficiency of Vitamin D and Calcium. In fact, it is easier to treat osteomalacia with Vitamin D and Calcium, and it takes only a short period of a few weeks before symptoms of bone pain and muscle weakness improve. As against that moderately severe osteoporosis will need few years of bisphosphonate therapy to increase the bone mass and the therapy might have to be continued lifetime.

BLOOD TRANSFUSION AND RISK OF CANCER

`We found no evidence that blood components originating from precancerous blood donors confer an increased cancer risk on the recipients compared with blood components from non-cancerous donors'

Although infectious diseases that could be transmitted by transfusion are fairly easy to identify, possible transmission of chronic diseases with unknown causes and long induction or latency periods is more difficult to address. Gustaf Edgren and colleagues did a retrospective cohort study with data gathered from blood bank registers in Sweden and Denmark to determine cancer incidence among patients who received blood from donors deemed to have a subclinical cancer at the time of donation. The researchers found no excess risk of cancer among such recipients compared with recipients of blood from non-cancerous donors. In a Comment, Garth Utter states that Edgren and colleagues have developed a uniquely powerful tool to ascertain possible long-term consequences of blood transfusion.

Lancet Oncol, 2007; 8 : 1670, 1724.

Ex. Hon. Physician, Jaslok Hospital and Bombay Hospital, Mumbai, Ex. Hon. Prof. of Medicine, Grant Medical College and JJ Hospital, Mumbai 400 008.

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