GASTRIC ACID SUPPRESSION IS ASSOCIATED WITH
INCREASED RISK OF PNEUMONIA
Current use of drugs that suppress gastric acid, including
H2 receptor antagonists and proton pump inhibitors,
is associated with a slightly increased risk of community
acquired pneumonia. Higher doses of PPIs are associated
with increasing risk. The risk is very low, and patients
currently taking these drugs can be equally well controlled
with a reduced dose or by stopping treatment altogether.
2004; 292 : 1955-60..
PRESCRIBE NSAIDs FOR OSTEOARTHRITIS OF THE
Non-steroidal anti-inflammatory drugs (NSAIDs) reduce
short term pain in osteoarthritis of the knee slightly
better than placebo, but there is no evidence of long
term benefit. In a meta-analysis of randomised, placebo
controlled trials, Bjordal and colleagues analysed data
on change in the overall intensity of pain for 7807
patients taking NSAIDs and 3038 receiving placebo. Given
the serious adverse effects of NSAIDs, they recommend
only limited use of these drugs in osteoarthritis of
BMJ, 2004; 329 : 1317.